Clinical xenotransplantation

Clinical xenotransplantation.

Two baboon liver xenografts transplanted to patients with B virus hepatitis supported life for 70 and 26 days but did not function optimally despite minimum or no histopathologic findings of overt humoral or cellular rejection in serial biopsies. However, there was evidence of complement activation in both cases, which in retrospect was thought to explain the unsatisfactory outcome. Strategies ...

Prospects of clinical xenotransplantation.

OUR two recent atte~pts ~t baboon-to-human xenotransplantatton faJled. I -. However. there were encouraging notations. First. the xenografts had no evidence of B virus infection during their posttransplant survival of 70 and 26 days in B virus carriers. Second. there also was little histopathologic evidence of humoral or cellular rejection of these livers. Yet. their function was suboptimal. If...

Progress towards clinical xenotransplantation.

Xenotransplantation has progressed from early heroic experiments on the path to meet the ever increasing demands of tissue and organ transplantation in patients with end-stage organ failure. The pig species is regarded as the most promising donor species. However, due to the evolutionary distance, innovative approaches are to be developed to permit life-supporting function in humans. Transplant...

Clinical Islet Xenotransplantation

Type 1 diabetes (T1D) is a major health problem throughout the world. In the U.S., it is estimated that about 1.5 million people suffer from T1D. Even when well controlled—by frequent monitoring of blood glucose and administration of insulin, the long-term complications of the disease are significant and include cardiovascular disease, nephropathy, retinopathy, and neuropathy (1). Here we revie...

22 Hepatic Xenotransplantation : Clinical Experience